In Depth Characterization of Complex PFAS Samples Using Rapid Screening, Suspect Screening, and Non-targeted RPLC-HRIM-MS Strategies

Emerging Environmental Applications for High Resolution Mass Spectrometry
Poster Presentation

Prepared by J. Krone, M. Fico, F. Strathmann
MOBILion Systems, 4 Hillman Drive, Suite 130, Chadds Ford, PA, 76049, United States


Contact Information: [email protected]; 817-357-5131

ABSTRACT

Per- and polyfluoroalkyl substances (PFAS) have been widely used in industrial and commercial applications since the 1950s due to their hydrophobic and lipophobic properties. These anthropogenic chemicals, characterized by strong carbon-fluorine bonds, resist biological and chemical degradation, raising concerns about bioaccumulation and adverse health effects. The persistent and widespread distribution of PFAS present an increasing challenge. While targeted monitoring methods (typically LC-MS/MS) address legacy PFAS, they fail to detect emerging compounds and transformation products. High-throughput, nontargeted analysis methods are essential for identifying unknown PFAS and providing comprehensive profiles of biomaterials and ecosystems. This study employs a novel high-resolution ion mobility (HRIM) technology to enhance throughput and coverage, offering deeper insights into complex PFAS samples.