High Throughput PFAS Analysis of Aqueous Phase Samples: ASTM D8421 Direct Injection on the SCIEX 7500 SystemPer- and Polyfluoroalkyl Substances (PFAS) in the Environment
Poster Presentation
Prepared by M. Shimizu1, I. Brooker2, O. Cawdell3
1 - Sciex, 6390 Joyce Dr., #100, Golden, United States (+1), 80403, United States
2 - Enthalpy Analytical, 2714 Exchange Drive, Wilmington, NC, United States
3 - Enthalpy Analytical, 1104 Windfield Way, El Dorado Hills, CA, United States
Contact Information: [email protected]; 910-833-0544
ABSTRACT
The growing need for efficient PFAS monitoring has increased interest in analytical workflows that minimize complexity, reduce costs, and support high-throughput screening. ASTM D8421 introduces a direct injection approach for quantifying PFAS in drinking water, eliminating the need for solid phase extraction (SPE) and the consumables associated with it. Using the SCIEX 7500 triple quad mass spectrometer, the method provides a streamlined, reliable workflow that reduces sample preparation time and simplifies laboratory operations. This direct analysis strategy, paired with a sensitive mass spectrometer, also reduces the use of costly isotopically labeled internal standards and minimizes contamination risks associated with sample handling. Using a 10 µL injection volume, this workflow can achieve method reporting limits (MRLs) of 5–25 ppt, supporting sensitive yet efficient routine monitoring. This workflow offers a practical, cost-efficient solution for laboratories seeking to improve throughput and reduce operational overhead in PFAS analysis.
