LC-MS/MS Robustness: a Real-world Case Study of PFAS TestingPer- and Polyfluoroalkyl Substances (PFAS) in the Environment
Poster Presentation
Presented by D. Tran
Prepared by K. Hup1, J. Steed2, B. Nieland2, S. Ouadi2, D. McMillan2, J. Stahl-Zeng2, A. Chahbouni1
1 - Het Waterlaboratorium, 6390 Joyce Drive #100, Golden, Colorado, 80403, United States
2 - SCIEX, , ,
Contact Information: [email protected]; 650-315-0311
ABSTRACT
Robustness can be defined as the ability to withstand or overcome adverse conditions or rigorous testing. Taken into the content of LC-MS/MS, robustness then relates directly to the fidelity of your analyses day-over-day, week-over-week and month-over-month. Demonstrating an LC-MS method is robust is laborious, as it requires a critical mass of longitudinal data, on a system running real-world samples to truly understand method performance within the broader content of expected intralaboratory variability. This study demonstrates 15 months of robustness for the SCIEX 7500 system in a laboratory analyzing PFAS in ground, surface and drinking water samples. The resulting control charts show acceptable response variability in quality control samples.
