Using High-Res MS to Explore the Chemical Space of PFAS Captured by Solid-Phase Extraction

Emerging Environmental Applications for High Resolution Mass Spectrometry
Oral Presentation

Prepared by D. Schiessel, R. Cahill
Babcock Laboratories, Inc., 6100 Quail Valley Ct, Riverside, CA, 92507, United States


Contact Information: [email protected]; 951-653-3351

ABSTRACT

One key component in evaluating a non-targeted workflow is the chemical space of the analysis which is limited by sampling, preparation, and analysis. Currently, the two most common methods used to determine Polyfluorinated Alkyl Substances (PFAS) in aqueous matrices employ weak-anion exchange (WAX) solid phase extraction (SPE) to preconcentrate the sample. This preparation step is necessary for non-targeted analysis (NTA) because high-resolution mass spectrometry (HRMS) is not sensitive enough to detect ultra-low levels of PFAS. This work will review a statistical analysis of NTA data obtained on drinking water samples with a focus on PFAS and classes beyond the scope of current targeted methods like perfluorosulfonamides. The primary comparison is two SPE techniques; one that preconcentrates the extract to dryness (EPA 533) and another which does not. It will also review some currently used SPE chemistry and the potential to capture the chemical space even outside the PFAS chemical space (eg: pesticides).