The Changing PFAS Landscape and EPA Method 1621

Polyfluoroalkyl Substances (PFAS) in the Environment
Poster Presentation

Prepared by J. Gandhi
Metrohm USA, 9250 Camden Field Parkway, Riverview, FL, 33578, United States

Contact Information: [email protected]; 813-316-4700


What we know about PFAS compounds is changing every day, as the list of compounds continues to grow and be detected in more products and the environment. Historically, targeted LC-MS/MS methods have been used to detect and quantify a limited list of these compounds, though there is increasing interest in non-targeted methods, which look at total fluorine and give a better picture of the overall impact. The US EPA has acknowledged this shift in thinking with the proposal of method 1621, which screens for adsorbable organic fluorine (AOF) using combustion ion chromatography (CIC). In this talk, details of EPA method 1621 will be discussed along with an optimized sample prep and CIC solution to comply with the method.