Interlaboratory Validation of D8421, Standard Test Method for Determination of Per- and Polyfluoroalkyl Substances (PFAS) in Aqueous Matrices by Co-solvation Followed by Liquid Chromatography Tandem Mass Spectrometry (LC/ MS/MS)

Polyfluoroalkyl Substances (PFAS) in the Environment
Oral Presentation

Prepared by L. Zintek1, W. Lipps2, D. Kleinmaier1, G. Schupp1
1 - US EPA, 536 South Clark Street, Chicago, IL, 60491, United States
2 - Shimadzu Scientific Instruments, Address: 7102 Riverwood Drive, Columbia, MD, 21046, United States


Contact Information: [email protected]; 312-886-2925

ABSTRACT

ASTM conducted an inter-laboratory study (ILS) to establish precision and bias for ASTM D8421 that employs liquid chromatography and tandem mass spectrometry (LC-MS/MS) to measure PFAS compounds. The focus of this ILS was on analyses of PFAS contaminants in various water matrices. The objectives of this study were to 1) characterize the performance of ASTM Standard D8421 in multiple laboratories 2) evaluate and, if appropriate, revise the quality control (QC) acceptance criteria in the method. The ultimate objective is that EPA propose and promulgate the ASTM Standard in 40 CFR part 136 for use in EPA's Clean Water Act programs. This presentation will elaborate on the precision and bias from the study.