Per- and Polyfluorinated Alkyl Compound (PFAS) Analysis in Cosmetics Using High Resolution Accurate Mass Spectrometry

Polyfluoroalkyl Substances (PFAS) in the Environment
Oral Presentation

Prepared by C. Butt1, H. Lee2, A. Rand3, M. Reyes1
1 - SCIEX, 500 Old Connecticut Path, Framingham, Massachusetts, 01701, United States
2 - SCIEX, 71 Four Valley Dr, Concord, Ontario, L4K 4V8, Canada
3 - Carleton University, Department of Chemistry, 320 Steacie Building, Ottawa, Ontario, K1S 5B6, Canada

Contact Information: [email protected]; 508-383-7416


Per- and polyfluorinated alkyl compounds (PFAS) have been detected in a wide range of cosmetics and personal care products. PFAS-containing cosmetics may act as human exposure sources through either dermal absorption or ingestion. Previous studies have shown that a large portion of the total fluorine in cosmetics is unaccounted for using traditional, targeted analysis techniques. Therefore, there is a need for non-targeted acquisition methods to comprehensively identify PFAS compounds in cosmetic samples. In this study we analyzed a series of cosmetic extracts on the SCIEX ZenoTOF 7600 system using non-targeted acquisition. Commercially available cosmetic samples were extracted with methanol using sonication and cleaned using ENVI-Carb SPE cartridges. Information dependent acquisition (IDA) was performed using the Zeno Trap to improve duty cycle thereby producing stronger MS/MS spectra for improved compound identification. Data were initially processed using suspect screening with MS/MS library matching for compound confirmation. A diverse range of PFAS were detected including perfluorinated carboxylic acids, mono- and di-alkyl fluorotelomer phosphates and fluorotelomer sulfonates. In addition, samples were interrogated using the peak finding algorithm in the SCIEX OS software. Additional PFAS were detected, including several PFAS compounds that have not been reported, to our knowledge.