A Comprehensive Workflow Approach for the Determination of PFAS in Wastewater

Polyfluoroalkyl Substances (PFAS) in the Environment
Poster Presentation

Presented by R. Luo
Prepared by M. Giardina, E. Parry, M. Giardina, T. Anumol, L. Wu, P. Batoon
Agilent Technologies, 2850 Centerville Rd, Wilmington, DE, 19808, United States

Contact Information: [email protected]; 302-636-8211


Per- and polyfluoroalkyl substances (PFAS) pose an increasing threat to the environment, animals, and human beings due to extreme chemical stability and bioaccumulation potential. Their detection at trace level is often interfered with by the environmental matrices and background contaminants. A comprehensive workflow was developed for the PFAS analysis in wastewater, based on the existing EPA draft Method 1633 with additional PFAS of varying size and functional group. This workflow contains off-line solid phase extraction (SPE), clean-up step, followed by LC-MS/MS analysis, and automatic reporting. The workflow demonstrates a reliable solution for the targeted analysis of PFAS in complex matrices with high robustness.