Multi-Laboratory Validation of SW-846 Method 8327, Per- and Polyfluoroalkyl Substances (PFAS) Using External Standard Calibration and Multiple Reaction Monitoring (MRM) Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS)
Polyfluoroalkyl Substances (PFAS) in the Environment - Session 5
Oral Presentation
Prepared by T. Strock1, K. Kirkland1, C. Langlois-Miller1, S. Fitz-James2, L. Gaines2, D. Reese3, S. Reimer4
1 - EPA Office of Resource Conservation and Recovery, 1200 Pennsylvania Ave. NW (5304P), Washington, DC, 20460, United States
2 - EPA Office of Superfund Remediation and Technology Innovation, 1200 Pennsylvania Ave. NW (5204P), Washington, DC, 20460, United States
3 - EPA Region 6, 2510 14th Street Suite 1212, Gulfport, MS, 39501, United States
4 - EPA Region 10, 7411 Beach Dr. E, Port Orchard, WA, 98366, United States
Contact Information: [email protected]; 703-603-8801
ABSTRACT
This presentation summarizes the results from multi-laboratory validation of a rapid and simple aqueous sample preparation method (SW-846 Method 3512) and determinative method (SW-846 Method 8327) for analysis of Per- and Polyfluoro Alkyl Substances (PFAS) in non-potable water matrices (groundwater, surface water, wastewater effluent). 24 target analytes were included in the scope of the study, including C4-C14 perfluorinated carboxylic acids, C4-C10 perfluorinated sulfonic acids, 4:2, 6:2, and 8:2 fluorotelomer sulfonic acids, N-methyl and N-ethyl perfluorooctane sulfonamidoacetic acids, and perfluorooctane sulfonamide. Metrics used for assessment of laboratory data will be presented along with precision and recovery of prepared concentrations in replicate samples across laboratories, performance of instrument and sample preparation quality controls, and identification of suspected causes of non-conforming data. This presentation will compare performance of target analytes and isotopically labeled analogs used as surrogates to examine the relative advantages of reporting recovery-corrected target concentrations calculated by an isotope dilution approach versus an external standard calibration as described in this method.
Polyfluoroalkyl Substances (PFAS) in the Environment - Session 5
Oral Presentation
Prepared by T. Strock1, K. Kirkland1, C. Langlois-Miller1, S. Fitz-James2, L. Gaines2, D. Reese3, S. Reimer4
1 - EPA Office of Resource Conservation and Recovery, 1200 Pennsylvania Ave. NW (5304P), Washington, DC, 20460, United States
2 - EPA Office of Superfund Remediation and Technology Innovation, 1200 Pennsylvania Ave. NW (5204P), Washington, DC, 20460, United States
3 - EPA Region 6, 2510 14th Street Suite 1212, Gulfport, MS, 39501, United States
4 - EPA Region 10, 7411 Beach Dr. E, Port Orchard, WA, 98366, United States
Contact Information: [email protected]; 703-603-8801
ABSTRACT
This presentation summarizes the results from multi-laboratory validation of a rapid and simple aqueous sample preparation method (SW-846 Method 3512) and determinative method (SW-846 Method 8327) for analysis of Per- and Polyfluoro Alkyl Substances (PFAS) in non-potable water matrices (groundwater, surface water, wastewater effluent). 24 target analytes were included in the scope of the study, including C4-C14 perfluorinated carboxylic acids, C4-C10 perfluorinated sulfonic acids, 4:2, 6:2, and 8:2 fluorotelomer sulfonic acids, N-methyl and N-ethyl perfluorooctane sulfonamidoacetic acids, and perfluorooctane sulfonamide. Metrics used for assessment of laboratory data will be presented along with precision and recovery of prepared concentrations in replicate samples across laboratories, performance of instrument and sample preparation quality controls, and identification of suspected causes of non-conforming data. This presentation will compare performance of target analytes and isotopically labeled analogs used as surrogates to examine the relative advantages of reporting recovery-corrected target concentrations calculated by an isotope dilution approach versus an external standard calibration as described in this method.
