Rapid Analysis of Haloacetic Acids, Bromate and Dalapon by Ion-chromatography Tandem Mass Spectrometry (IC-MS/MS) in Drinking Water

Oral Presentation

Prepared by T. Anumol1, J. Matthew3, J. Gandhi4, S. Mohsin1, S. Snyder1
1 - Agilent Technologies, Inc., 1133 E James E Rogers Way, 108 Harshbarger, Tucson, AZ, 85721, United States
3 - US EPA, Region 6, US Environmental Protection Agency, Region 6, Houston, , Houston, TX, 75202, United States
4 - Metrohm USA, 15421 Vantage Pkwy, Suite 150, , Houston,, TX, 77032, United States

Contact Information: [email protected]; 412-656-0490


Haloacetic acids (HAAs) and bromate are disinfection byproducts formed on oxidation of organic matter in drinking and wastewaters. Both HAAs and bromate are considered carcinogenic and as a result have maximum contaminant limits (MCLS) set by the EPA in the low part per billion range. Traditionally, analysis of HAAs has been performed by gas-chromatography coupled with an electron capture detector (GC-ECD). This method is labor-intensive and involves a tedius extraction step, while the ECD detector is not specific and interferences from other organic molecules co-eluting with HAAs can be a significant issue. Similarly, bromate is normally analysed with ion-chromatography with a conductivity detector and can suffer from similar issues with a non-specific detector. The study analyzed thirteen HAAs, bromate and dalapon (herbicide) using an IC coupled to tandem mass spectrometer to add selectivity and specificity to the analysis. Further, this method did not require any extraction process and detection limits of less than 0.2 µg/L (ppb) was achievable with just a 150 µL sample injection. This is also the first study to analyze the more toxic iodinated-HAAs by IC-MS/MS. This paper will present method development and validation details including method reporting limits, matrix spike recoveries in different source waters, reproducibility and linearity of calibration. This method holds significant benefits to regulatory authorities and contract labs as it allows rapid analysis of HAAs, bromate and Dalapon in water with significant time, labor and cost savings.